Description: Inhibin, Activin and Follistatin Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Regulatory Functions in System and Cell Biology Author(s): Toshihiro Aono, Hiromu Sugino, Wylie W. Vale Format: Paperback Publisher: Springer-Verlag New York Inc., United States Imprint: Springer-Verlag New York Inc. ISBN-13: 9781461273202, 978-1461273202 Synopsis Inhibin, activin, and follistatin were originally discovered as hormonal fac- tors a decade ago. Subsequent studies revealed that they are widely distrib- uted anatomically and have multiple biological functions in a wide range of cells and tissues. Since the last Symposium three years ago, there has been remarkable progress toward defining activin's roles in controlling hormone secretion, cell differentiation and proliferation, mesoderm induction in em- bryos, nerve cell survival, and promotion of bone growth. Furthermore, the characterization of activin receptors as serine and threonine kinases and the identification of intracellular mediators such as the Smads have provided key elements for the eventual understanding of signaling mechanisms for activin and the other members of the TGF-beta superfamily. The unknown in this integrative field, however, remains far greater than the known. For ex- ample, we are just beginning to exploit the recently improved activin, inhibin, and follistatin two-site assays for the evaluation of the physiological and pathophysiological functions of these proteins. Also, we have only a rudi- mentary understanding of the mechanisms by which inhibin blocks activin, and many steps in the pathways linking the formation of ligand-receptor(s) complexes to transcriptional regulation are unclear. The aim of the Third Symposium was to bring together scientists from diverse fields to share technical and conceptual developments. The program was framed with the intention to include a wide range of timely research topics.
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Location: Aldershot
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Book Title: Inhibin, Activin and Follistatin
Number of Pages: 335 Pages
Publication Name: Inhibin, Activin and Follistatin: Regulatory Functions in System and Cell Biology
Language: English
Publisher: Springer-Verlag New York Inc.
Item Height: 244 mm
Subject: Medicine, Biology
Publication Year: 2012
Type: Textbook
Item Weight: 621 g
Author: Toshihiro Aono, Wylie W. Vale, Hiromu Sugino
Item Width: 170 mm
Series: Serono Symposia Usa
Format: Paperback
